Hormone imbalance or thyroid issues can contribute to depression and anxiety by changing how the brain and nervous system function. Shifts in estrogen, progesterone, testosterone, cortisol, or thyroid hormones may affect mood, energy, sleep, and stress tolerance. At Optimal Longevity MD, your evaluation can include detailed hormone and thyroid testing, with options like BHRT therapy and thyroid support when needed, so that mood care includes the physical drivers behind your symptoms.